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Effect of compound 11d dosing on liver PSR staining in a mouse CCl4-induced liver fibrosis model. Mice received 1 μL/g of 25% CCl4 diluted in olive oil ip twice-weekly for 8 weeks with compound 11d dosed orally bid during the last 4 weeks (n = 8 per group). Representative PSR-stained sections of mouse liver (A) and quantitation of PSR-stained sections (B) are shown. Data were analyzed by one-way ANOVA.
