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Exemplars of reported PfGSK3 and PfPK6 inhibitors25,27−29 and IKK16, a dual PfGSK3 and PfPK6 ligand identified as the starting point for this work. aSelectivity metric definition: S10 (1 μM) = number of kinases having an experimental value percent of control (PoC) ≤10% at 1 μM divided by the total number of distinct kinases tested. This metric quantifies the percentage of kinases in a panel that a compound binds to at a chosen threshold at a particular screening concentration.
