Table 6. Activity of IKK16 Analogues against P. falciparum Blood Stage Proliferation with the Associated Cytotoxicity against HepG2 Cells.

compound	Pf3D7 EC50 (nM ± SEM)a	% viability@200 nMb	% viability@2 μMb
IKK16	280 ± 2	110	103
12	60 ± 5	100	97
18b	541 ± 29	105	82
18m	810 ± 19	110	87
18n	760 ± 61	87	66
18o	646 ± 10	83	55
18q	607 ± 16	98	79
18r	991 ± 65	94	61
18s	300 ± 9	83	47
18t	322 ± 7	95	84
23c	576 ± 28	87	65
23d	552 ± 37	113	34
23e	1400 ± 13	102	65
23f	2600 ± 35	99	54

^aEC₅₀ values were determined using the SYBR green I-based assay with 2-fold dilutions, presented as mean values performed in triplicate.

^b% of viable cells after incubation with 200 nM and 2 μM of the test compounds, presented as an average of two experiments performed in quadruplicate.