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| compound | S10 (1 μM)a | no. of kinase hits |
|---|---|---|
| IKK16 | 0.10 | 41 |
| 9g | 0.08 | 32 |
| 18n | 0.25 | 100 |
| 18r | 0.22 | 88 |
| 23d | 0.26 | 103 |
| 23e | 0.16 | 64 |
Selectivity metric definition: S10 (1 μM) = number of kinases having an experimental value PoC ≤10% at 1 μM divided by the total number of distinct kinases tested. This metric quantifies the percentage of kinases in a panel that a compound binds to at a chosen threshold at a particular screening concentration.
