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Selectivity analysis of 8RK59 toward UCHL1 and PARK7 and structural characterization of 8RK64 binding to PARK7. (A) Structures of 8RK64 and 8RK59. (B) Labeling of PARK7 and UCHL1 with 8RK59. UCHL1 and PARK7 were incubated with 8RK59, resolved by SDS-PAGE, and analyzed by fluorescence scanning (top) and Coomassie staining (bottom). DMSO and BodipyFL were used as negative controls. (C) Co-crystal structure of the 8RK64-PARK7 complex (PDB: 7PA2). PARK7 in green and 8RK64 in cyan.
