. 2022 Sep 26;65(19):12933–12955. doi: 10.1021/acs.jmedchem.2c00785

Table 6. Inhibition of Compounds 13 14, 15, 27, Tiludronate Disodium, and Alendronate Sodium against Three MMPs^a.

IC₅₀ (μM)
class	cpd.	MMP-1	MMP-2	MMP-3
synthesized diphosphonates	13	53 ± 3	79 ± 2	33 ± 11
	14	>100	>100	>100
	15	>100	>100	>100
FDA-approved diphosphonates	tiludronate disodium	50 ± 10	>100	>100
FDA-approved diphosphonates	alendronate sodium	>100	>100	>100
hydroxamate	27	>100	>100	>100

Means and SD of two independent experiments, >100: IC₅₀ is higher than 100 μM.

Table 6. Inhibition of Compounds 13 14, 15, 27, Tiludronate Disodium, and Alendronate Sodium against Three MMPsa.