Table 1. PK Parameters after 25 mg/kg Inhalative Administration and 100 mg/kg Peroral Administration^a.

	25 mg/kg inhalative	100 mg/kg peroral
plasma Tmax [h]	0.33 ± 0.1	2.5 ± 0.7
plasma Cmax [ng/ml]	236.47 ± 29.8	357.00 ± 171.8
plasma AUC 0-t [ng/ml·h]	2896.63 ± 269.6	1061.49 ± 290.1
plasma Vz/F_obs [l/kg]	141.07 ± 48.1	131.34
plasma Cl/F_obs [ml/min/kg]	83.92 ± 52.1	1162.74
plasma t1/2 [h]		1.3
plasma MRT [h]		2.57
BALF Cmax [ng/ml]	2330.33 ± 1034.4
BALF AUC 0-t [ng/ml·h]	5162.20 ± 1163.6
ratio BALF AUC 0-t/Plasma AUC 0-t	1.7
ELF Cmax [μg/ml]	433.52 ± 222.6
ELF AUC 0-t [μg/ml·h]	1042.34 ± 586.9
ratio ELF AUC 0-t/plasma AUC 0-t	359
lung tissue Cmax [ng/g]	261,748 ± 1294.4

^at_1/2: half-life, T_max: time point at maximal concentration, C_max: maximal concentration, AUC 0-t: area under the curve/exposure from time 0-t, MRT: mean residence time, Vz/F_obs: fractionated observed volume of distribution, and Cl/F_obs: fractionated observed clearance.