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. 2022 Sep 6;26(20):5202–5212. doi: 10.1111/jcmm.17544

FIGURE 1.

FIGURE 1

EDIL3 promoted dermal microvascular formation of psoriasis in vivo. (A) Schematic diagram for intradermal administration of EDIL3 or 0.9% normal saline (NS) on day 1–4 or day 1–6 during the application of IMQ in BALB/c mice. A half of mice in each group were sacrificed on days 4 and 7 to conduct experiments. (B) The clinical manifestations and H and E staining of the mice back skin treated for 6 consecutive days with Vaseline cream or IMQ and injected with EDIL3 or NS. (C) Epidermis thickness of the back skin was measured on the seventh day under a microscope. (D) The frozen sections of mice back skin were analysed using immunofluorescence staining for CD31 (red, ECs surface marker) and DAPI (blue, cell nucleus) on day 4. (E) The frozen sections of mice back skin were analysed using immunofluorescence staining for CD31 and DAPI on day 7. The arrows pointed to the microvessels (magnification 10×)