FIGURE 7.

SNORA70E binds and regulates RAP1B expression. There is a binding site between SNORA70E and RAP1B (A). The overexpression of SNORA70E increased the RAP1B protein level (B). DKC1 bind with RAP1B mRNA (C). Silencing RAP1B in SNORA70E overexpression cells inhibited cell proliferation (D–E), migration (G), invasion (H), and induced apoptosis (F), reduced the levels of RAP1B, β‐catenin, PI3K, AKT1, mTOR, and MMP9 proteins (I). Data is calculated and shown as the mean ± SD (error bars) from three independent repeats. *p < 0.05. (Student's t‐test).