Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
X-ray crystal structure of the mammalian serine/threonine protein kinase WNK1. (A) WNK1 (PDB 6CN9). Ribbon diagram mainly blue, with the activation loop in red. Closeup of active site highlighting the unique lysine in WNK1, the Mg2+ binding aspartic acid (oxygens red), and an inhibitory chloride ion in 6CN9 (magenta). (B) Key characteristics of WNK1. (C) Chemical structure of WNK463, a previously reported pan-inhibitor of WNK.
