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. 2022 Aug 22;13(10):1582–1590. doi: 10.1021/acsmedchemlett.2c00228

Table 3. Synthesis of N-arylated Heliamine Derivatives 4.

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a

The yields in parentheses are from results by the reaction using homogeneous palladium catalyst; reaction conditions: 2 (2.0 equiv), 3 (0.5 mmol), Pd2(dba)3 (4 mol %), (±)-BINAP (8 mol %), NaOtBu (2.0 equiv), toluene (1.5 mL), 100 °C, 30 min, then reflux, 10 h, NR is no reaction.