Skip to main content
. 2022 Sep 26;13(10):1598–1605. doi: 10.1021/acsmedchemlett.2c00279

Scheme 2-1. Synthesis Routes of Quinoline, Aldehyde, and Fluorine Scaffolds.

Scheme 2-1

Reagents and conditions: (a) ethyl vinyl ether, AcOH, 25 °C → 100 °C; (b) N-bromosuccinimide (NBS), conc. H2SO4, 25 °C; (c) NHMe2, H2O, 80 °C; (d) 1,2,3-triazole, K2CO3, DMF, 100 °C; (e) tetrabutylammonium fluoride (TBAF), tetrahydrofuran (THF), 70 °C; (f) TREAT HF, 130 °C.