Table 5. Pharmacokinetic Properties of Compounds in Rats^a.

compound	metabolic stability rat/human (%)b	CLtot (mL/min/kg)c	Vdss (L/kg)	t1/2 (h)	F (%)c	serum fu (%)	solubility (μM) pH 1.2/pH 6.8/pH 6.8 with TCA	EPSAd
2	29/3	6.8	0.1	0.7	ND	1.1	ND/ND/26	113
11	53/18	11.4	0.8	1.6	ND	0.1	ND/ND/NT	88
15	60/20	5.7	0.7	2.0	0.2	0.1	ND/ND/NT	93
16	63/23	8.2	1.9	3.9	3.3	0.1	ND/ND/10	92

^aND: not detected; NT: not tested.

^bMetabolic stability using human and rat hepatic microsomes.

^cAll compounds were administered to rats by intravenous administration at 1 μmol/kg solution and oral administration at 2 μmol/kg suspension.

^dExposed polar surface area (EPSA) analysis by supercritical fluid chromatography.