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. 2022 Oct 17;23:220. doi: 10.1186/s13059-022-02785-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Trait-cell type association using the pancreas panels. A Association results using the five pancreas panels. B–D Demonstration and comparison of three subnetworks: T1D in the beta cell from the GSE85241 panel (B), T2D in the beta cell from the E-MTAB-5061 panel (C), and T2D in the beta cell from the GSE85241 panel (D). In all networks, node color is proportional to the corresponding GWAS signals and node size is proportional to the average gene expression in the corresponding cell type