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. 2022 Oct 17;23:215. doi: 10.1186/s13059-022-02784-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PAR1 phylogenetic tree and sequence alignment between great ape species. The total alignment consists of 620,054 syntenic sites of which 239,799 are putatively neutral (highlighted in yellow). As indicated by letters in the tree diagram, the species are as follows, from top to bottom: human (H), chimpanzee (C), gorilla (G), orangutan (O) and macaque (M). The number associated with each branch label is the divergence rate ratio with respect to the human rate (presented in parentheses), since the branching of the great ape ancestor (red point)