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. 2022 Oct 17;23:219. doi: 10.1186/s13059-022-02780-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The relationship between methylation conservation and model accuracy across species. A Taxonomy tree and accuracy for four species in 4mC dataset. Two species (i.e., F. vesca and C. equisetifolia) with higher accuracy are grouped in red, while the other two species (i.e., S. cerevisiae and Tolypocladium) with lower accuracy are grouped in blue. B The motif logo analysis on F. vesca and C. equisetifolia. C The motif logo analysis on S. cerevisiae and Tolypocladium. D The accuracy heatmap of cross-species validation on 4mC dataset