Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 17;23:219. doi: 10.1186/s13059-022-02780-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Interpretable analysis of multi-scale information processing. A The comparison of single scales including 3-mer, 4-mer, 5-mer, and 6-mer, respectively. B The comparison of multi-scale combinations. C The attention map to illustrate the information captured at 3-mer scale on one randomly selected sequence. Two sub-figures visualize the change of information captured before and after training, respectively. D The attention map to illustrate the information captured at 6-mer scale. E–G Interpretable illustrations of the motifs learnt by our model in three species covering three methylation types, including 4mC_Tolypocladium, 5hmC_H.sapiens, and 6mA_C.equisetifolia, respectively. The left part figure clearly shows which region the model is more focused on by using heatmap from 0 to 1. The closer the score is to 1, the darker the color and the more important the region considered by the model. The p-value was calculated using TOMTOM by comparing our iDNA-ABF learnt motifs with STREME motifs. The p-value in STREME was calculated by a one-sided binomial test. The motifs within the gray dashed anchor boxes were extracted for pair comparisons