FIGURE 2.

Probability of target attainment for the two targets (A) 100% fT > MIC and (B) 50% fT > 4xMIC (effectively 100% fT > 4xMIC for continuous infusion). PTA was simulated for intermittent administration every eight (q8h) and 6 h (q6h), extended infusion q8h and q6h and lasting half of a dosing interval, and continuous infusion. The colors represent different weight groups and MIC₅₀ (2 mg/L), MIC₉₀ (4 mg/L), and the EUCAST MIC breakpoint for P. aeruginosa (16 mg/L) are represented by the dashed vertical lines. The dashed horizontal lines illustrate that 95% of the simulated population have reached the specified fT > MIC target. CI, continuous infusion; EI, extended infusion; IA, intermittent administration; MIC, minimum inhibitory concentration; PTA, probability of target attainment