FIGURE 3.

Steady state piperacillin concentrations for continuous infusion of 300 and 400 mg/kg/day (maximum 16 000 mg/day) according to body weight in 10 000 simulated children. (A) Concentrations for the complete population, with 95th interval (2.5th to 97.5th percentile) indicated to enable comparison with the P. aeruginosa breakpoint for the two targets of 100% fT > MIC (16 mg/L) and 50/100% fT > 4xMIC (64 mg/L). (B) The 10 000 children divided into body weight categories, with the distribution and 95th interval indicated. The maximum daily dose is reached at 53.3 kg (300 mg/kg) and 40 kg (400 mg/kg), resulting in overlapping distributions. CI, continuous infusion; MIC, minimum inhibitory concentration