TABLE 1.
Characteristics and cancer incidence rates of patients initiating antiretroviral therapy at Newlands Clinic between 2004 and 2017 (N = 3442)
| Characteristic | Patients n (%) | Person‐years at risk | Cancer cases (n) | Incidence rate per 100 000 PY (95% CI) |
|---|---|---|---|---|
| All | 3442 | 19 346 | 66 | 341 (268–434) |
| Sex | ||||
| Female | 2235 (64.9) | 12 994 | 50 | 385 (292–508) |
| Male | 1207 (35.1) | 6351 | 16 | 252 (154–411) |
| Age group (years) | ||||
| 16–35 | 1489 (43.3) | 8275 | 22 | 265 (175–404) |
| 36–50 | 1579 (45.9) | 9053 | 34 | 376 (268–526) |
| > 50 | 374 (10.9) | 2018 | 10 | 496 (266–921) |
| ART initiation period (years) | ||||
| 2004–2007 | 653 (19.0) | 6344 | 20 | 315 (203–489) |
| 2008–2010 | 944 (27.4) | 7025 | 26 | 370 (252–544) |
| 2011–2013 | 761 (22.1) | 3834 | 13 | 339 (197–584) |
| 2014–2017 | 1084 (31.5) | 2143 | 7 | 327 (156–685) |
| Education | ||||
| Primary or none | 833 (24.2) | 5478 | 26 | 475 (323–697) |
| Secondary or tertiary | 2609 (75.8) | 13 868 | 40 | 288 (212–393) |
| Employment | ||||
| Employed | 1261 (36.6) | 6564 | 23 | 350 (233–527) |
| Unemployed | 1970 (57.2) | 11 396 | 40 | 351 (257–479) |
| Unknown | 211 (6.1) | 1386 | 3 | ‐ |
| CD4 count categories at ART initiation (cells/mm3) | ||||
| <100 | 1039 (30.2) | 6271 | 33 | 526 (374–740) |
| 100–199 | 974 (28.3) | 6397 | 17 | 266 (165–427) |
| ≥200 | 1410 (41.0) | 6656 | 16 | 240 (147–392) |
| Unknown | 19 (0.6) | 21 | 0 | ‐ |
| WHO clinical stage for HIV disease at ART initiation | ||||
| Stage 1 | 1144 (33.2) | 4915 | 10 | 203 (109–378) |
| Stage 2 | 890 (25.9) | 5488 | 17 | 310 (193–498) |
| Stage 3 | 1061 (30.8) | 6952 | 29 | 417 (290–600) |
| Stage 4 | 343 (10.0) | 1977 | 10 | 506 (272–940) |
| Unknown | 4 (0.1) | 14 | 0 | ‐ |
Note: Incidence rates are unadjusted. Data source: Linked Zimbabwe National Cancer Registry and Newlands Clinic electronic records.
Abbreviations: ART, antiretroviral therapy; CI, confidence interval; PY, person‐years.