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. 2022 Oct 3;13:993788. doi: 10.3389/fimmu.2022.993788

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Copyright © 2022 Huang, Yan, Dong, Jiao, Wang, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MST1 is downregulated in endometriosis-related peritoneal macrophages. (A, B) Intraperitoneal cells were collected from patients with or without endometriosis and then analyzed by flow cytometry. A higher percentage of CD68⁺CD86⁺ macrophages was present in the peritoneal cavity of the control group, while the percentage of CD68⁺CD163⁺ macrophages was higher in the peritoneal cavity of endometriosis patients. (C) The IL-10 concentration of human peritoneal fluid supernatant with or without endometriosis. (D, E) Representative western blot of protein expression of MST1, and p38-MAPK. (F) The mRNA level of MST1 and p38-MAPK by RT-qPCR. (G) The location of MST1 and p38-MAPK by immunofluorescence staining. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Control group peritoneal macrophages vs. endometriosis group peritoneal macrophages). Values represent the mean ± standard error.