Table 3.

Univariate and multivariate Cox analyses of the overall survival of patients with NSCLC. Cox analysis was performed on the effect of single factors, such as age, gender, and tissue type, on the survival rate of the patients with NSCLC. Statistically significant variables, namely, clinical staging, lymph node metastasis, degree of differentiation, and miR-92a expression, in the univariate Cox analysis were included in the multivariate Cox regression analysis.

Variable	Univariate Cox analysis HR (95% CI)	P value	Multivariate Cox analysis HR (95% CI)	P value
Age (yr)
<60	1.3 (0.74–2.6)	.682	–	–
≥60
Gender
Male	1.4 (0.87–2.48)	.213	–	–
Female
Smoking history
Yes	0.97 (0.59–1.68)	.758	–	–
No
Organization type
Squamous cell carcinoma	1.1 (0.72–1.83)	.327	–	–
Adenocarcinoma
Clinical staging
I/II	2.2 (1.2–2.91)	.009	0.96 (0.53–2.7)	.869
III/IV
Lymph node metastasis
No	4.5 (2.4–8.5)	<.001	4.0 (2.1–7.7)	<.001
Yes
Distant metastasis
No	2.2 (1.0–4.6)	.0435	1.3 (0.61–2.5)	.792
Yes
Differentiation
Highly and moderately differentiated	2.5 (1.5–4.8)	.0472	1.6 (0.87–2.7)	.316
Poorly differentiated
Tumor size
≥3 cm	1.7 (0.87–2.39)	.219	–	–
<3 cm
Expression of miR–92a
High expression	2.4 (1.2–4.3)	.003	1.8 (1.0–3.2)	.036
Low expression

NSCLC = non-small cell lung cancer.