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. 2022 Oct 17;117:e220058. doi: 10.1590/0074-02760220058

Mycobacterium leprae molecular viability analysis in oral and nasal scrapings from multibacillary patients. M. leprae molecular viability over the first five months of the multidrug therapy (MDT) regime. For each patient’s temporal series (oral or nasal), the highest viability observed was arbitrary determined as 100% of viable M. leprae load, while 0% indicates the absence of 16S rRNA or absence of viable M. leprae. The black line represents conventional MDT (rifampicin, clofazimine, and dapsone); the red line represents alternative MDT (rifampicin, clofazimine, and ofloxacin); the broken line represents interruption of treatment. The red asterisk indicates erythema nodosum leprosum occurrence; the triangle indicates pneumonia; the square indicates dapsone-associated hemolytic anaemia; the circle indicates treatment-related fever and asthenia. The non-parametric Friedman test was performed by comparing each time point with the next one, where * means p value < 0.05, ** means p < 0.005, and *** means p < 0.001.

Mycobacterium leprae molecular viability analysis in oral and nasal scrapings from multibacillary patients. M. leprae molecular viability over the first five months of the multidrug therapy (MDT) regime. For each patient’s temporal series (oral or nasal), the highest viability observed was arbitrary determined as 100% of viable M. leprae load, while 0% indicates the absence of 16S rRNA or absence of viable M. leprae. The black line represents conventional MDT (rifampicin, clofazimine, and dapsone); the red line represents alternative MDT (rifampicin, clofazimine, and ofloxacin); the broken line represents interruption of treatment. The red asterisk indicates erythema nodosum leprosum occurrence; the triangle indicates pneumonia; the square indicates dapsone-associated hemolytic anaemia; the circle indicates treatment-related fever and asthenia. The non-parametric Friedman test was performed by comparing each time point with the next one, where * means p value < 0.05, ** means p < 0.005, and *** means p < 0.001.