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. 2022 Oct 17;17(10):e0276241. doi: 10.1371/journal.pone.0276241

Fig 3. Correlations between summed IFN-γ, IL2, and IFN-γ+IL2 responses to S sub-pools and serum IgG responses to Spike glycoprotein.

Fig 3

Summed IFN-γ, IL2, and IFN-γ+IL-2 responses (spot forming cells/million PBMCs, sfc/m) to S glycoprotein correlated with serum IgG responses to Spike glycoprotein. Total n per graph = 198: Uninfected unvaccinated n = 11, Uninfected vaccinated n = 179, Infected vaccinated n = 8. Of note, 8 individuals in the uninfected unvaccinated group and 2 individuals in the uninfected vaccinated group had values of zero for frequencies of cells producing both IFN-γ and IL-2 in response to S peptides. While the zero values were used for statistical analyses, they were plotted as values of 1 to enable visualization on the log axis. Correlations were assessed using the non-parametric Spearman’s correlation analysis.