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. 2022 Oct 17;17(10):e0275337. doi: 10.1371/journal.pone.0275337

Fig 4. Association of direct biomarkers of IVH with vascular risk factors in type 2 diabetes.

Fig 4

We crossed our direct IVH biomarkers with clinical data. We investigated the association of plasma absorbance at 398 nm (A-D, I-L) and 575 nm (E-H, M-P) with subgroups of patients with T2D. First, we assessed the correlation of Abs398 and Abs575 with glycated hemoglobin (Hb1Ac) levels (r = -0.12 and -0.11, respectively. p>0.2 for both). Next, we assessed their association with obesity, dyslipidemia and hypertension (HTN) (A-H). Abs398 and Abs575 were significantly increased in obese vs. non-obese patients with T2D. Finally, we assessed their association with peripheral neuropathy, nephropathy, retinopathy or macroangiopathy (I-P). (*) p<0.05 vs. Controls (#) p = 0.051 vs Controls. (see Table 2 for adjusted logistic regressions using Log-transformed absorbances).