TABLE 3.
Cytotoxicity against HIV-coated CD4 cells and HIV-infected FS4 cells
| Source of effector cells (n)a | Value for target
cells in the presence of serumb
|
|||||
|---|---|---|---|---|---|---|
| IIIB-coated CD4 cells
|
HSV-infected FS4
cells
|
|||||
| %
Lysisc
|
P valued | %
Lysisc
|
P valued | |||
| HIV seronegative | HIV seropositive | HSV seronegative | HSV seropositive | |||
| HIV-infected children (12) | 0 | 4.4 ± 2.3 | 0.1643 | 11.4 ± 1.6 | 36.4 ± 2.5 | <0.05 |
| Uninfected children (10) | 0 | 8.4 ± 1.3 | <0.05 | 9.0 ± 0.7 | 35.5 ± 3.3 | <0.05 |
| HIV-infected adults (6) | 13.4 ± 5.6 | 16.5 ± 4.0 | 0.3494 | 16.0 ± 1.6 | 41.6 ± 3.7 | <0.05 |
| Uninfected adults (6) | 0.8 ± 1.3 | 15.6 ± 3.4 | <0.05 | 16.6 ± 1.0 | 42.5 ± 3.9 | <0.05 |
a
PBMC were prepared as described in Materials and Methods.
b
HIV- and HSV-seropositive and -seronegative sera obtained from adults.
c
Means ± standard errors.
d
Data were analyzed by Student’s t test.