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. 2022 Sep 26;4(5):fcac245. doi: 10.1093/braincomms/fcac245

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Blood–brain barrier leakage can be observed starting in lower vessel grades. (A) Aβ and fibrin(ogen) stains of representative examples of Grades 0–4 vessels. (B) Per cent of vessels within each vessel grade with evidence of fibrin(ogen) within their vessel wall across temporo-occipital sections from two ‘targeted’ cases with CAA (regions targeted based on high regional CMB burden). (C) Summary of fibrin vessel wall ratings in all vessels studied across two targeted cases with CAA. Number of vessels (Cases 1 and 2): Grade 0 = 11, 8; Grade 1 = 2, 7; Grade 2 = 26, 22; Grade 3 = 8, 9; Grade 4 = 10, 2.