Table 1.
Functional contribution of CD103+ tissue-resident lymphocytes. Engagement of CD103 with E-cad on CD103+ lymphocytes, with or without TCR co-stimulation
| Lymphocyte | Cellular Function | Tissue | Requirement for TCR Co-Stimulation | References |
|---|---|---|---|---|
| CD8 | Enhanced cytotoxicity | Tumors and grafts | Yes | (15, 41, 42) |
| Regulatory T cell (Treg) | Enhanced suppression | Skin, colon, and tumor | Unknown | (18, 43–45) |
| CD4 | Enhanced proliferation and Th1/17 cytokine production | Gastric mucosa | Yes | (46) |
| Thymocytes | Enhanced proliferation | Thymus | Unknown | (47) |
| γδ T cells | Facilitating apoptotic enterocyte shedding via degranulation-independent granzyme release | Villous epithelium | No | (48) |
| Regulating duration of IEL/epithelial contact | Villous epithelium and small intestinal tumors | No | (49–51) |
E-cad, E-cadherin; TCR, T cell receptor.