Table 3.
Multiple regression assessing association between cardiorespiratory fitness (VO2peak) and cerebral hemodynamics in males and females with CVD risk factors
| Model | With CVD Risk Factors |
|||||
|---|---|---|---|---|---|---|
| Combined |
Female |
Male |
||||
| B (95% CI) | β | B (95% CI) | β | B (95%CI) | β | |
| MCA PI | ||||||
| 1 | ||||||
| V̇o2peak | 0.000 (−0.003, 0.003) | 0.00 | 0.005 (−0.002, 0.011) | 0.26 | 0.001 (−0.005, 0.006) | 0.05 |
| Age | 0.004 (0.001, 0.007) | 0.32 | 0.007 (0.003, 0.011) | 0.62 | 0.003 (−0.003, 0.008) | 0.18 |
| 2 | ||||||
| V̇o2peak | 0.002 (−0.002, 0.007) | 0.17 | 0.008 (0.002, 0.015) | 0.44 | −0.001 (−0.007, 0.005) | −0.06 |
| Age | 0.005 (0.001, 0.009) | 0.41 | 0.010 (0.006, 0.014) | 0.90 | 0.000 (−0.006, 0.007) | 0.02 |
| BMI | 0.001 (−0.006, 0.009) | 0.05 | 0.012 (0.004, 0.020) | 0.47 | −0.009 (−0.021, 0.004) | −0.31 |
| (Female sex) | 0.054 (−0.007, 0.115) | 0.25 | ||||
| MCA mean velocity | ||||||
| 1 | ||||||
| V̇o2peak | 0.002 (−0.417, 0.421) | 0.00 | 0.300 (−0.671, 1.271) | 0.11 | 0.309 (−0.240, 0.857) | 0.23 |
| Age | −0.364 (−0.76, 0.032) | −0.20 | −0.557 (−1.141, 0.028) | −0.35 | 0.204 (−0.373, 0.780) | 0.15 |
| 2 | ||||||
| V̇o2peak | 0.106 (−0.408, 0.620) | 0.07 | 0.048 (−0.992, 1.088) | 0.02 | 0.178 (−0.395, 0.752) | 0.13 |
| Age | −0.465 (−0.922, −0.008) | −0.30 | −0.795 (−1.483, −0.106) | −0.50 | 0.000 (−0.643, 0.643) | 0.00 |
| BMI | −0.853 (−1.747, 0.042) | −0.30 | −0.875 (−2.246, 0.495) | −0.24 | −0.804 (−1.991, 0.383) | −0.29 |
| (Female sex) | 6.593 (−0.731, 13.917) | 0.26 | ||||
BMI, body mass index; CVD, cardiovascular disease; MCA, middle cerebral artery; PI, pulsatility index; V̇o2peak, peak oxygen consumption. Bold denotes significant contributor at P < 0.05. Parentheses around predictor denote they are not included in sex-specific models. Modality was not included as covariate in analyses for adults without CVD risk factor since it accounted for hypertension diagnosis. Males, n = 30; females, n = 36.