FIGURE 6.

Schematic representation of the different in vitro and in vivo models that can be used to study functional effects of mutations affecting developmental and epileptic encephalopathies (DEEs) causative genes. Regardless of the starting point, researchers can move from one model to another based on the type of functional assay they want to apply and the physiological process they want to study. BEH, behavioral studies; EPS, electrophysiological studies; ICC, immunocytochemistry; IHC, immunohistochemistry; ISH, in situ hybridization; LI, live imaging; MRI, magnetic resonance imaging; PR, proteomics; TR, transcriptomics; 2D, 2-dimensional.