Fig. 4.

Time of test performance after the first shot of vaccination of the Viramed-Tests, with positive detection of S1/S2-specific antibodies until day 160. The colored area depicts the time interval in which, at least for Biontech-vaccinated, no humoral immunity to SARS-CoV-2 spike protein was expected (until day 14 after first vaccination) [19]. Distributed all over the age groups, there were samples with a negative test result belonging to 13 different subjects (age range 18–86 years, median 47 years) after this 14 day interval. The two samples connected by an arrow indicate results of a subject that was initially tested negative but showed seroconversion at a later test.