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. 2022 Oct 4;11:e72128. doi: 10.7554/eLife.72128

Figure 1. Telocytes in the periodontal ligament (PDL).

(a) PDL single cells from control mice and ligature-treated mice were combined and clustered into 18 clusters. (b) Identification of each cluster. Telocyte clusters were identified by CD34+ and CD31-. Macrophages are in four clusters. (c) In vitro cell culture with CD1 PDL cells at passage 1 shows characteristic telocyte structure, including podoms (red arrows, the dilated portion) and podomers (between two arrows, the thin segments between podoms). (d) Wnt1 lineage-traced cells (GFP in green) were cultured and stained with CD34 in red, which show piriform cell body and moniliform podoms (red arrows) and podomers. (e) Telocytes (CD34+CD31-) was detected near blood vessel (CD34+CD31+) in vivo, CD34 in green, CD31 in red. White arrow indicates the small nuclei, and white triangle shows the elongation of telocyte respectively. (f) CD34 expression was compared with pericyte markers, CD146 (Mcam) and NG2 (Cspg4) expression.

Figure 1.

Figure 1—figure supplement 1. Heatmap of cell clusters show telocytes distinct from other mesenchymal cells.

Figure 1—figure supplement 1.

Figure 1—figure supplement 2. Telocyte identification makers. Panel (b) shows a zoomed region of boxed region in (a).

Figure 1—figure supplement 2.