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. 2022 Sep 27;99(13):e1402–e1413. doi: 10.1212/WNL.0000000000200898

Figure 2. Mean DNA Methylation Age Advancement Values in Aging in ADNI Within Each of the 3 Diagnostic Categories.

Figure 2

Values are grouped by diagnostic category at the time of interview: CN (blue bars), MCI (gold bars), and Dementia (grey bars). The 3 diagnostic status groups did not differ significantly from one another on either of the first-generation DNA methylation clocks (Horvath and Hannum clocks) or on the second-generation clocks (PhenoAge and GrimAge). By contrast, individuals with MCI or Dementia had faster DunedinPACE scores than those who were CN. Bars represent means, and whiskers represent 95% CIs. Values are standardized to mean = 0, SD = 1. CN = cognitively normal; MCI = mild cognitive impairment.