. 2022 Oct 10;2022:5081413. doi: 10.1155/2022/5081413

Table 1.

Correlation analysis between GXYLT2 and relate genes and markers of immune cells in TIMER.

Description	Gene markers	None		Purity
Description	Gene markers	Cor	p	Cor	p
CD8+ T cell	CD8A	0.353	∗∗∗	0.134	∗
CD8+ T cell	CD8B	0.305	∗∗∗	0.156	∗∗

T cell (general)	CD3D	0.298	∗∗∗	0.03	0.561
	CD3E	0.403	∗∗∗	0.133	∗
	CD2	0.389	∗∗∗	0.126	∗

B cell	CD19	0.381	∗∗∗	0.185	∗∗∗
B cell	CD79A	0.405	∗∗∗	0.187	∗∗∗

Monocyte	CD86	0.575	∗∗∗	0.386	∗∗∗
Monocyte	CD115 (CSF1R)	0.656	∗∗∗	0.502	∗∗∗

TAM	CCL2	0.574	∗∗∗	0.411	∗∗∗
	CD68	0.406	∗∗∗	0.228	∗∗∗
	IL10	0.619	∗∗∗	0.488	∗∗∗

M1 macrophage	INOS (NOS2)	0.174	∗∗∗	0.131	∗
	IRF5	-0.107	∗	-0.105	∗
	COX2 (PTGS2)	0.127	∗	0.031	0.549

M2 macrophage	CD163	0.693	∗∗∗	0.565	∗∗∗
	VSIG4	0.679	∗∗∗	0.537	∗∗∗
	MS4A4A	0.668	∗∗∗	0.531	∗∗∗

Neutrophils	CD66b (CEACAM8)	0.02	0.683	0.047	0.372
	CD11b (ITGAM)	0.638	∗∗∗	0.485	∗∗∗
	CCR7	0.044	0.378	-0.06	0.254

Natural killer cell	KIR2DL1	0.221	∗∗∗	0.081	0.122
	KIR2DL3	0.229	∗∗∗	0.057	0.278
	KIR2DL4	0.21	∗∗∗	0.026	0.619
	KIR3DL1	0.196	∗∗∗	0.067	0.201
	KIR3DL2	0.18	∗∗∗	0.031	0.558
	KIR3DL3	0.031	0.53	-0.014	0.794
	KIR2DS4	0.18	∗∗∗	0.04	0.439

Dendritic cell	HLA-DPB1	0.513	∗∗∗	0.309	∗∗∗
	HLA-DQB1	0.431	∗∗∗	0.225	∗∗∗
	HLA-DRA	0.451	∗∗∗	0.243	∗∗∗
	HLA-DPA1	0.469	∗∗∗	0.278	∗∗∗
	BDCA-1 (CD1C)	0.266	∗∗∗	0.082	0.117
	BDCA-4 (NRP1)	0.48	∗∗∗	0.38	∗∗∗
	CD11c (ITGAX)	0.641	∗∗∗	0.479	∗∗∗

Th1	T-bet (TBX21)	0.375	∗∗∗	0.143	∗∗
	STAT4	0.435	∗∗∗	0.206	∗∗∗
	STAT1	0.335	∗∗∗	0.156	∗∗
	IFN-γ (IFNG)	0.272	∗∗∗	0.089	0.0891
	TNF-α (TNF)	0.282	∗∗∗	0.16	∗∗

Th2	GATA3	-0.387	∗∗∗	-0.266	∗∗∗
	STAT6	-0.179	∗∗∗	-0.125	∗
	STAT5A	0.28	∗∗∗	0.122	∗
	IL13	0.185	∗∗∗	0.041	0.434

Tfh	BCL6	-0.109	∗∗∗	-0.08	0.125
Tfh	IL21	0.172	∗∗∗	0.092	0.0782

Th17	STAT3	0.393	∗∗∗	0.273	∗∗∗
Th17	IL17A	-0.098	∗	-0.157	∗∗

Treg	FOXP3	0.446	∗∗∗	0.277	∗∗∗
	CCR8	0.45	∗∗∗	0.297	∗∗∗
	STAT5B	0.214	∗∗∗	0.226	∗∗∗
	TGFβ (TGFB1)	0.357	∗∗∗	0.261	∗∗∗

T cell exhaustion	PD-1 (PDCD1)	0.394	∗∗∗	0.17	∗∗
	CTLA4	0.391	∗∗∗	0.168	∗∗
	LAG3	0.394	∗∗∗	0.186	∗∗∗
	TIM-3 (HAVCR2)	0.602	∗∗∗	0.42	∗∗∗
	GZMB	0.369	∗∗∗	0.118	∗

p < 0.05 was considered to be statistically significant (^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001).