Table 8.

Cox Regression Analysis of Prognostic Factors in Patients with CRC

Clinical Variables	B	SE	Wald	df	HR	95% CI	P value
	Univariate cox analysis
Sex(male vs female)	−0.293	0.347	0.711	1	0.746	0.378–1.473	0.399
Age(≥60 vs <60)	1.889	0.534	12.513	1	0.151	0.053–0.431	<0.001**
Tumor location (Colon vs Rectum)	1.128	0.411	7.546	1	3.089	1.382–6.909	0.006**
TNM stages(Stage III-IV vs Stage I-II)	1.213	0.393	9.526	1	3.364	1.557–7.268	0.002**
MSI status(MSI vs MSS)	0.084	0.391	0.046	1	1.088	0.505–2.342	0.830
F. nucleatum (Positive vs Negative)	0.690	0.345	4.0	1	1.994	1.014–3.922	0.045*
HER-2(Positive vs Negative)	0.575	0.346	2.758	1	0.563	0.286–1.109	0.097
CD31(Positive vs Negative)	0.382	0.370	11.064	1	1.465	0.7709–3.627	0.302
D2-40(Positive vs Negative)	0.382	0.370	11.064	1	1.465	0.7709–3.627	0.302
CgA(Positive vs Negative)	0.256	0.732	0.122	1	0.774	0.184–3.251	0.122
Syn(Positive vs Negative)	0.470	0.533	0.777	1	1.600	00.563–4.548	0.378
	Multivariate Cox analysis
Sex(male vs Female)	0.105	0.418	0.063	1	1.110	0.490–2517	0.802
Age(≥60 vs <60)	2.080	0.567	13.472	1	0.125	0.041–0.379	<0.001**
Tumor location (Colon vs Rectum)	0.965	0.489	3.891	1	2.626	1.006–6.852	0.049*
TNM stages(Stage III-IV vs Stage I-II)	1.311	0.438	8.939	1	0.270	0.114–0.637	0.003**
MSI status(MSI vs MSS)	0.507	0.454	1.246	1	0.602	0.247–1.467	0.264
F. nucleatum (Positive vs Negative)	0.861	0.426	4.085	1	0.423	0.183–0.974	0.043*

Notes: *p <0.05 and **p<0.01 were considered to be statistically significant.

Abbreviations: B, beta; SE, standard error; df, degree of freedom; HR, hazard ratio;95% CI, 95% confidence interval; CRC, colorectal cancer; F. nucleatum, Fusobacterium nucleatum; HER-2, human epidermal growth factor receptor-2; MSI, microsatellite instability; MSS, microsatellite stability; Syn, synaptophysin; CgA, chromogranin A.