Table 5.

The five genes and the linkage density to the respective pathway

S. No.	Description	Density	Interaction number	Overlap gene number	Overlapped gene(s)
1	TNF signaling	0.03233	212	2	TNF
2	PIP3 activates AKT signaling	0.03029	1,160	22	AKT1/PDPK1/MAPK3
3	MAP2K and MAPK activation	0.06191	369	8	MAPK3
4	AKT phosphorylates targets in the cytosol	0.06833	112	2	AKT1/CDKN1A
5	Insulin receptor signaling cascade	0.04171	317	6	MAPK3
6	Insulin-like growth factor I binding	0.05857	96	2	ITGAV/ITGB4
7	VEGF signaling pathway	0.06469	588	7	AKT1/MAPK3
8	MAPK1/MAPK3 signaling	0.02869	1,227	27	MAPK3
9	IGF factor receptor signaling pathway	0.07046	105	1	AKT1
10	Negative regulation of insulin receptor signaling pathway	0.04785	164	1	PRKCZ
11	VEGFA-VEGFR2 Pathway	0.0563	797	14	PDPK1/AKT1
12	Insulin/IGF pathway-MAPK kinase/MAPK cascade	0.08817	381	6	MAPK3
13	Insulin/IGF pathway-protein kinase B signaling cascade	0.05119	267	4	AKT1/PDPK1
14	PI3K cascade	0.0305	200	5	PDPK1
15	Signaling by insulin receptor	0.02979	333	6	PDPK1/MAPK3
16	Signaling by VEGF	0.05317	824	16	PDPK1/AKT1

TNF, tumor necrosis factor; MAPK, mitogen-activated protein kinase; VEGF, vascular endothelial growth factor; MAP, mitogen-activated protein; IGF, Insulin-like growth factor; PI3K, phosphoinositide 3-kinase.