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. 2022 Sep 11;18(15):5724–5739. doi: 10.7150/ijbs.76140

Figure 5.

Figure 5

Smad7 KD promotes hypertrophic scar formation in HDAC5 KO mice. (A) Images of scars 14 days post-incision and gross area quantification at all examined time points. (Scale bar = 3 mm). (B) Images of H&E-stained sections and cross-section size quantification in different groups. The dashed lines outline the scar (scale bar = 200 µm). (C, D) Images of picrosirius red-stained sections under ordinary light and polarized light and collagen density quantification in different groups (scale bar = 100 µm). (E) The orientation of collagen fibers was quantified from picrosirius red using Orientation J software. The color representation reflects the different orientations. Data are presented as the mean ± SD (n = 9 biologically independent animals). *P < 0.05, ***P < 0.001.