Figure 7.

LMK235 attenuates hypertrophic scar formation in vivo. (A) Images of scars 14 days postincision and gross area quantification at all examined time points (scale bar = 3 mm). (B) Images of H&E-stained sections and cross-section size quantification in different groups. The dashed lines outline the scar (scale bar = 200 µm). (C, D) Images of picrosirius red-stained sections under ordinary light and polarized light and collagen density quantification in different groups (scale bar = 100 µm). (E) The orientation of collagen fibers was quantified from picrosirius red using Orientation J software. The color representation reflects the different orientations. Data are presented as the mean ± SD (n = 9 biologically independent animals). **P < 0.01, ***P < 0.001, NS = not significant.