Table 2.

Contributions of organotypic tissue slice model from normal organs in antitumor invasive drug discovery

Models	Sketch diagram	Contributions	Reference
Organotypic brain slice culture		Jasplakinolide, Rac1 inhibitor NSC23766, and tranilast significantly decrease the tumor cell invasion on brain slices.	52, 58, 77
Organotypic cerebellar slice culture		Epidermal growth factor accelerates the invasion of medulloblastoma cells on cerebellar slices.	53
Tissue-based liver-kidney-on-a-chip		A CXCR4 small-molecule antagonist AMD3100 effectively halts the liver tropism of breast cancer extracellular vesicles.	54
Organotypic hippocampal slice culture		Cannabinoids influence the migratory and mechanical properties of tumor cells on organotypic hippocampal slices.	57