Table 4.

The promising applications of different organotypic tumor slice cultures in antitumor drug discovery

Models	Sketch diagram	Small-molecule drug therapy	Immunotherapy	Radiotherapy	Adoptive cellular therapy	Reference
Filter-supporting tumor slice culture		√	√	√	√	25, 35, 41, 49, 66, 81
Floating tumor slice culture		√	√	√	×	26, 33, 68, 69, 72, 75
3D-tumor slice culture		√	√	×	×	27
Tumor slice culture on a rotating platform		√	×	×	×	47
Collagen-supporting tumor slice culture		√	×	×	×	80
Tumor slice culture on a microfluidic platform		√	×	×	×	84
Patient-derived tumor fragment culture		×	√	×	×	85

The application that has been described in the publications is marked with “√”, otherwise is marked with “×”.