Table 2.
Chronological Summary of Series LITT Therapy in Gliomas
| Author | Location | Laser Tx Time | LOS, days | Complications |
|---|---|---|---|---|
| Reimer et al., 199820 | Frontal (3), temporal (1) | 3–10 minutes | NR | Transient aphasia (1), intracranial hemorrhage (1) |
| Leonardi and Lumenta, 200221 | Frontal (7), frontotemporal (2), frontoparietal (2), temporal (1), parietal (5), parietooccipital (6), thalamic (1) | 2.1–27.2 minutes | NR | Transient hemiparesis (2), brain abscess (1), SSI (2), seizure (1) |
| Schwarzmaier et al., 200522 | Temporal (1) parietooccipital (1) |
NR | NR | None |
| Schwarzmaier et al., 200623 | Temporal (1), frontal (3), frontoparietal (1), frontotemporal (2), temporoparietal (2), parietal (2), genu of CC (1), occipital (1), parietooccipital (3) | NR | 12.0 ± 4.2 | Transient monoparesis (1), neutropenia (3), thrombocytopenia (1), elevated transaminases (1) |
| Carpentier et al., 201224 | Temporal (2), CC (1), frontal (1) | 30–180 seconds | 1 | Seizure (1), dysphasia (1)—resolved day 7, CSF leak (1) |
| Sloan et al., 201325 | Temporal (2), frontal (3), parietal (3), temporoparietal (1), temporooccipital (1) | 7.5–50.2 minutes | 2–7 | Transient monoparesis/dysphasia (1) Transient hemiparesis/homonymous hemianopia (1) ICH secondary to pseudoaneurysm 6 weeks post LITT (1)—coiled Hemiplegia (1)—function regained @ 8 weeks |
| Mohammadi et al., 201426 | Frontal (15), thalamus (7), temporal (5), parietal (5), insular (2), CC (1) | NR | 1–29 | Transient hemiparesis (5) Permanent hemiparesis (2) Seizure (1) Hyponatremia (1) Bilateral DVT (1) Infection (2) |
| Thomas et al., 201627 | Butterfly (5), insular (2), thalamus (1), motor (3), speech (3), temporal (1), splenium of CC (2), cingulate (1), insular (2) | NR | NR | Seizure (1), worsening functional status (2) |
| Leuthardt et al., 201628 | Frontal (7), temporal (4), parietal (6), parietooccipital (1), thalamic (1) | NR | 1–5 | None |
| Beaumont et al., 201829 | Frontal CC (7), parietal CC (2), callosal (6) | 3.7 ± 2.2 vs. 0.6 ± 0.4 minutes | 1–11 | Transient hemiparesis (2), permanent hemiplegia (2), edema (1), ventriculitis (1), hydrocephalus (1), visual field defect (1) |
| Mohammadi et al., 201930 | lobar (13), thalamus (7), callosum (2), insula (2) | 2–10 minutes | 1–26 | Transient hemiparesis (2) Permanent hemiplegia (4) DVT (1) Moderate/severe ICH—treated conservatively (2) |
| Shah et al., 201831 | Splenium (1), frontal (1), parietooccipital (1), postcingulate (1), precuneus (1), genu (1) | NR | NR | None |
| Hafez et al., 202032 | Insular (1) | NR | 1 | None |
| Kamath et al., 201933 | Frontal (14), temporal (8), parietal (9), occipital (1), parieto-occipital (4), temporo-occipital (4), CC (8), insular (2), thalamic (8) | 2–10 minutes | 3.2 ± 4.6 | Edema (3), seizure (3), death (2), hydrocephalus (1), hyponatremia (1), infection (1) |
| Arocho-Quinones et al., 202034 | Frontal (11), temporal (13), parietal (6), occipital (3), thalamus (10), hypothalamus (6), basal ganglia (6), periventricular (17), cerebellar (14) | NR | NR | ICH (2), transient deficits (11), permanent deficits (5), death (2), malposition of laser probe (3), edema (2), hydrocephalus (4) |
| Murayi et al., 202035 | Thalamic (11) | NR | 3 | Transient deficit (4), hydrocephalus (2) |
| Traylor et al., 202136 | Deep-seated (35), non-deep seated (34) | NR | NR | Seizure (4), transient dysphasia (11), new persistent motor deficit (4), worsened pre-existing motor deficit (13) |
LITT, laser interstitial thermal therapy; LOS, length of stay; NR, not recorded; SSI, surgical-site infection; CC, corpus callosum; CSF, cerebrospinal fluid; ICH, intracranial hemorrhage; DVT, deep-vein thrombosis.