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. 2022 Mar 22;29(10):1355–1372. doi: 10.1038/s41417-022-00451-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A–D The cell cycle was examined via flow cytometry with PC9 (A) and A549 (C) cells transfected with siALKBH5 (#1 and #3) or siNC. The bar charts indicate the percentage of cells in each cell cycle phase [n = 6 for PC9 (B), n = 3 for A549 cells (D)]. E, F Apoptotic cells were determined using flow cytometric analysis of PC9 cells transfected with siALKBH5 (#1 and #3) or siNC. E Percentage of the apoptotic cells in which both propidium iodide and annexin V were positive are shown in a representative scatter plot. F The apoptosis rate in ALKBH5 knockdown was compared with siNC and shown as a bar chart (n = 3). G, H Cisplatin- or gefitinib-induced apoptotic cells were determined via flow cytometry with PC9 cells transfected with siALKBH5 or siNC. G Percentage of apoptotic cells shown in a representative scatter plot. H The cisplatin- or gefitinib-induced apoptosis rate in ALKBH5 knockdown was compared with siNC and shown as a bar chart (n = 3). I, J Apoptotic cells were determined via flow cytometry with A549 cells transfected with siALKBH5 or siNC. I Percentage of the apoptotic cells shown in a representative scatter plot. J Apoptosis rate in ALKBH5 knockdown was compared with siNC and shown as a bar chart (n = 6). K, L Cisplatin-induced apoptotic cells were determined via flow cytometric analysis of A549 cells transfected with siALKBH5 or siNC. K Percentage of the apoptotic cells shown in a representative scatter plot. L The cisplatin-induced apoptosis rate in ALKBH5 knockdown was compared with siNC and shown as a bar chart (n = 3). Results were presented as mean ± SD. *P < 0.05, **P < 0.01, ^***P < 0.001, ^****P < 0.0001 indicates a significant difference between the indicated groups.