Figure 6.

Scheme of the logic gates for the multi-trigger RNA/DNA hybrid system. The system is comprised of a 3-input AND gate and a NOT gate that are constructed by coupling the sense hybrid (activated by the connective tissue growth factor (CTGF) that used as an RNA trigger) with the antisense hybrid (designed to repress the strand exchange in the presence of a trigger sequence derived from the Kirsten rat sarcoma proto-oncogene (KRAS) mRNA). Both hybrids and the CTGF trigger are required for the dsRNA release, while the presence of the KRAS trigger inhibits strand exchange ²².