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. 2022 Oct 3;12(16):6915–6930. doi: 10.7150/thno.78171

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Anti-CDCP1 antibody ch10D7 accumulates in CDCP1 expressing cancer tissues in vivo. A. Schematic depicting generation of radiolabelled ch10D7-⁸⁹Zr and 10D7-⁸⁹Zr (top), and the experimental plan for the in vivo PDAC model (bottom). B. Representative PET-CT images of NSG mice carrying subcutaneous xenografts of PDAC TKCC2.1 cells. Left: PET imaging (ventral view maximum intensity projection) at 24, 48 and 72 h after antibody injection. Right: PET/CT imaging (ventral and lateral views maximum intensity projection) at 144 h after antibody injection. C. Quantitative distribution analysis of ⁸⁹Zr-DFO-10D7 and ch10D7-⁸⁹Zr 144 h post injection (n = 3) in normal tissues and xenografts. Statistical significance between different groups was performed using a two-way ANOVA test with *** p<0.001.