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. 2022 Sep 25;12(16):6848–6864. doi: 10.7150/thno.73078

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IDentif.AI workflow to optimize and design combination therapy regimens against M. abscessus. The workflow begins by selecting repurposed drug candidates that are currently used against other NTM species and those that demonstrated in vitro efficacy against M. abscessus in previous studies. The dose response curves of the selected drugs are then generated, and two clinically actionable concentrations are determined. Subsequently, OACD-designed combinations are experimentally validated, and IDentif.AI harnesses the data to interrogate the drug interaction space. Efficacious IDentif.AI-designed combinations are rapidly pinpointed and subsequently, experimentally validated and compared to standard of care regimens. In the final step, IDentif.AI-pinpointed unique 2-drug combinations are included for further synergy analyses.