Table 2.
Clinically actionable drug concentration levels for IDentif.AI's interrogation of drug interactions. Concentration levels corresponding to the OACD design are level 0, which is the absence of a drug, and level 1 and level 2 representing two clinically actionable drug concentrations 70. Level 1 and level 2 concentrations were selected based on absolute IC10 and IC20 for LZD, MEM, and CLR. Concentrations for AMK, RFB, and LVX were selected based on 5% and 10% Cmax. AMK: amikacin, CLR: clarithromycin, LVX: levofloxacin, LZD: linezolid, MEM: meropenem, and RFB: rifabutin.
| Drug | Level 0 (μg /mL) | Level 1 (μg /mL) | Level 2 (μg /mL) |
|---|---|---|---|
| LZD | 0 | 0.508 | 0.966 |
| AMK | 0 | 0.105 | 0.210 |
| MEM | 0 | 0.670 | 2.996 |
| CLR | 0 | 0.0325 | 0.0442 |
| RFB | 0 | 0.0188 | 0.0375 |
| LVX | 0 | 0.465 | 0.930 |