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. 2022 Sep 25;12(16):6848–6864. doi: 10.7150/thno.73078

Table 3.

IDentif.AI-designed combinations and their corresponding, rank, concentrations, and %Inhibitions are listed below. The rank is out of 729 total possible combinations. Data points are presented as mean ± propagated SD (N = 3).

Rank Top 2-Drug Combinations IDentfi.AI %Inhibition Measured %Inhibition
190 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 41.84 57.69±6.21
339 Levofloxacin
(0.930 μg/mL)		 Meropenem
(0.670 μg/mL)		 34.54 50.40±5.38
341 Levofloxacin
(0.930 μg/mL)		 Amikacin
(0.105 μg/mL)		 34.41 /
363 Levofloxacin
(0.930 μg/mL)		 Rifabutin
(0.0375 μg/mL)		 33.41 54.32±6.01
396 Levofloxacin
(0.930 μg/mL)		 Amikacin
(0.210 μg/mL)		 31.75 50.71±9.55
Rank Top 3-Drug Combinations IDentfi.AI %Inhibition Measured %Inhibition
71 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Rifabutin
(0.0375 μg/mL)		 48.01 58.33±4.99
97 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Linezolid
(0.966 μg/mL)		 46.35 51.97±7.03
105 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Clarithromycin (0.0442 μg/mL) 46.00 /
120 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Amikacin
(0.105 μg/mL)		 45.35 /
129 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Rifabutin
(0.0188 μg/mL))		 44.93 /
Rank Top 4-Drug Combinations IDentfi.AI %Inhibition Measured %Inhibition
18 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Amikacin
(0.105 μg/mL)		 Clarithromycin (0.0442 μg/mL) 52.56 51.75±6.01
19 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Linezolid
(0.966 μg/mL)		 Rifabutin
(0.0375 μg/mL)		 52.52 55.80±6.56
26 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Amikacin
(0.105 μg/mL)		 Rifabutin
(0.0375 μg/mL)		 51.52 /
36 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Linezolid
(0.966 μg/mL)		 Clarithromycin (0.0442 μg/mL) 50.50 /
39 Levofloxacin
(0.930 μg/mL)		 Meropenem
(2.996 μg/mL)		 Linezolid
(0.508 μg/mL)		 Rifabutin
(0.0375 μg/mL)		 50.26 /