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The schematic presentation depicts the potential mechanism by which PA-S14 inhibits tubular cell senescence and renal fibrosis. As an activator of LKB1, PA-S14 may attenuate tubular cell senescence and renal fibrosis by promoting autophagy and mitochondrial biogenesis. The underlying mechanisms are related to its activation of AMPKα. These effects lead to mitochondrial healthy, which further reduces tubular cell senescence and retards renal fibrosis.
