Table 4.

NIR-PIT for non-malignant diseases.

Target molecule	IR700 carrier	TSPC	Noncancerous diseases	Model	Ref.
FAP	Antibody	28H1-700DX	Arthritis	In vitro and in vivo collagen-induced arthritis mouse model	188
FAP	Antibody	28H1-IR700	Systemic sclerosis	In vitro (2D and 3D cultures)	191
GLP-1R	Ligand, peptide	Exendin-4-IR700	Hyperinsulinemic hypoglycemia	In vitro and in vivo; s.c.	185
Gp41	Antibody	7B2-IR700	HIV	In vitro	176
IgY	Antibody	CA-IgY-IR700	Candida albicans infection	In vitro and in vivo CA-infected cutaneous ulcers mouse model	174
IL-31	Ligand	IL-31K138A-SNAP-IR700	Itch	In vitro and in vivo mouse models of atopic dermatitis, of cutaneous amyloidosis, and of psoriasis	182
IsaA	Antibody	1D9-IR700	Staphylococcus aureus infections	In vitro and in vivo Galleria mellonella larval infection model, human postmortem orthopedic implant infection model	173
TrkA/ P75	Ligand	NGFR121W-SNAP-IR700	Acute, inflammatory, neuropathic, and joint pain	In vitro and in vivo mouse models of pain	179
TrkB	Ligand	BDNFSNAP-IR700	Mechanical pain hypersensitivity	In vitro and in vivo mouse pain models	177

s.c, subcutaneous