Table 1.
Demographic characteristics of the ADNI and NACC cohorts.
| Dataset | ADNI (n = 2619) |
NACC (n = 2025) |
||||
|---|---|---|---|---|---|---|
| Subject characteristics | CN (n = 782) |
MCI (n = 1089) |
AD (n = 748) |
CN (n = 1281) |
MCI (n = 322) |
AD (n = 422) |
| Age, mean (sd) | 77.3 (5.6) | 76.5 (7.3) | 76.5 (7.3) |
69.1 (9.4)* (p-val < 0.01) |
74.4 (8.5)* (p-val < 0.01) |
73.9 (8.8)* (p-val: < 0.01) |
| Sex, n (%) | ||||||
| Male | 394 (50.4%) | 659 (60.5%) | 406 (54.3%) |
489 (38.2%)* (p-val < 0.01) |
128 (39.8%)* (p-val < 0.01) |
219 (49.5%) (p-val:0.433) |
| Female | 388 (49.6%) | 430 (39.5%) | 342 (45.7%) |
792 (61.8%)* (p-val < 0.01) |
194 (60.2%)* (p-val < 0.01) |
223 (50.5%)* (p-val:0.02) |
| Education, average years (sd) | 17.2 (3.1) | 16.7 (3.2) | 16.1 (3.5) |
16.3 (2.6)* (p-val < 0.01) |
15.7 (2.8)* (p-val < 0.01) |
15.1 (3.3)* (p-val < 0.01) |
| APOE4, n (%) | 224 (28.6%) | 567 (52.1%) | 496 (66.3%) |
479 (37.4%)* (p-val < 0.01) |
146 (45.3%)* (p-val:0.03) |
202 (45.7%)* (p-val < 0.01) |
Significance of differences between NACC and ADNI for each cognitive category are reported. Statistical significance (at p-value < 0.05) is indicated by *.